P46

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p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation

Limited information is available on the surface molecules that are involved in natural killer (NK) cell triggering. In this study, we selected the BAB281 monoclonal antibody (mAb) on the basis of its ability to trigger NK-mediated target cell lysis. BAB281 identified a novel NK cell-specific surface molecule of 46 kD (p46) that is expressed by all resting or activated NK cells. Importantly, unl...

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The archaeal DNA primase: biochemical characterization of the p41-p46 complex from Pyrococcus furiosus.

We characterized the primase complex of the hyperthermophilic archaeon, Pyrococcus furiosus. The two proteins, Pfup41 and Pfup46, have similar sequences to the p48 and p58 subunits, respectively, of the eukaryotic DNA polymerase alpha-primase complex. Unlike previously reported primases, the Pfup41 preferentially utilizes deoxyribonucleotides for its de novo synthesis, and moreover, it synthesi...

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P46 - Neck circumference may be related with severe asthma in children

Method Children with asthma who were followed in our outpatient department of pediatric allergy unit were consecutively recruited. Asthma severity was graded according to NAEPP guidelines. Patients were categorized into two groups; children with intermittent and mild persistent asthma formed Group 1 (mild asthma) whereas children with moderate and severe persistent asthma formed Group 2 (severe...

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Natural Killer p46 Controls Hepatitis B Virus Replication and Modulates Liver Inflammation

Natural killer (NK) cells play an important role in hepatitis B virus (HBV) infection control, and are regulated by a complex network of activating and inhibitory receptors. However, NK cell activity in HBV patients remains poorly understood. The objective of this study was to investigate the phenotypic and functional characteristics of circulating NK cells in patients during different chronic ...

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Identification of the alpha-enolase P46 in the extracellular membrane vesicles of Bacteroides fragilis

BACKGROUND Members of the Bacteroides fragilis group are the most important components of the normal human gut microbiome, but are also major opportunistic pathogens that are responsible for significant mortality, especially in the case of bacteraemia and other severe infections, such as intra-abdominal abscesses. Up to now, several virulence factors have been described that might explain the i...

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ژورنال

عنوان ژورنال: European Journal of Cancer Supplements

سال: 2015

ISSN: 1359-6349

DOI: 10.1016/j.ejcsup.2015.08.057